PTH-128 The Frax Algorithm is of Limited Utility in Predicting Osteoporosis in Coeliac Disease: Abstract PTH-128 Table 1
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چکیده
منابع مشابه
Parathyroid hormone (PTH)-related protein(1-36) is equipotent to PTH(1-34) in humans.
Humoral hypercalcemia of malignancy (HHM) results from the production of PTH-related protein (PTHrP) by human tumors. One previous study has reported the results of human (h) PTHrP(1-34) infusion into humans. In that report, hPTHrP(1-34) was found to be qualitatively similar to but 3- to 10-fold less potent than hPTH(1-34). Because hPTHrP(1-36) and not hPTH(1-34) is likely to be the actual amin...
متن کاملThe use of PTH in the treatment of osteoporosis.
Anabolic drugs have recently widened therapeutic options in osteoporosis treatment, as they influence processes associated with bone formation to a greater extent and earlier than bone reabsortion. They positively affect a number of skeletal properties besides bone density, as intermittent administration of parathyroid hormone (PTH) results in an increase in the number and activity of osteoblas...
متن کاملPTH(1-84)/PTH(7-84): a balance of power.
This review considers many new basic and clinical aspects of parathyroid hormone (PTH). We focus especially on the identification of PTH fragments and how they may relate to renal failure, diagnosis, and treatment of secondary hyperparathyroidism and renal osteodystrophy. The biosynthesis and metabolism of PTH, measurement of circulating forms of PTH, the effects of PTH on receptor activation a...
متن کاملDifficulties With Use of PTH and PTH, for the Prevention and Treatment of Osteoporosis 1. Mechanism of Action PTH and PTH, are stimulators of bone turnover; they affect both osteoblastic formation
sl.lg~--~~~ xwstinns with repard to clinical trials and consq@: fqrms,“~,g appropriate. However, I do not . --_,_ a--------~---~ believe that this nroblem is a-&-&or one assoc&ed -.. ------:-r------~-~ ~.I 1 With parathyroid hOhone since o$eo@i-coma, is ri me, and only occurs at high doses in the rapidly developing young animals. I have enclosed my SUI lmary of the consideratjons that n~~&to.,&...
متن کاملDisruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss
BACKGROUND Hyperparathyroidism in humans and continuous parathyroid hormone (cPTH) treatment in mice cause bone loss by regulating the production of RANKL and OPG by stromal cells (SCs) and osteoblasts (OBs). Recently, it has been reported that T cells are required for cPTH to induce bone loss as the binding of the T cell costimulatory molecule CD40L to SC receptor CD40 augments SC sensitivity ...
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ژورنال
عنوان ژورنال: Gut
سال: 2013
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2013-304907.615